Isothermal Titration Calorimeter (ITC)

Isothermal Titration Calorimeter (ITC): Installation and on-site system handover; for the characterization of protein-ligand and protein-protein interactions in enzyme and protein development; investigation of enzymes, receptors, and binding proteins regarding their affinity and binding specificity towards substrates, cofactors, photocatalysts, regulatory molecules, or other proteins; quantitative recording of these interactions within large variant libraries and combinatorial protein-ligand approaches; automation required for high sample throughput; calorimetric measurement necessary for systems only partially analyzable by optical or chromatographic titrations; device must be capable of quantitatively and thermodynamically characterizing biomolecular interactions in solution; determination of dissociation constant, stoichiometry, binding enthalpy, and binding entropy from measured heat changes for a complete thermodynamic description of the interaction.

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